Application of chemistry in Medicine.
The labels of medicines show the amounts of the different ingredents eg iron tablets may contain 200mg of iron or a painkiller may contain 500mg of paracetamol.How accurate are they?
Measuring the active ingredients in medicines can be achieved by titration and other simple laboratory techniques.But these are not reliable enough especially when working with medicines that are needed in micrograms or where an overdose might be harmful.Quality control in the pharmaceutical industry is ensured in a number of ways.The precise quantities of ingredients for any batch of medicine are measured and recorded.Then random samples from each batch are selected and tested. The tablets or other medicines are crushed if necessary and dissoved in a known solvent often methanol.This is filtered and then diluted.Standard solutions are made accurately using pure active drug to a precise concentration.Both the random samples and the standard solution are passed through a high performance liquid chromatograph (HPLC) and the quantities are compared.
HPLC is widely used to check the quantities of active ingredients in medicines.The result of this process show if the avearge content of the medicine lies within the accepted limits of variation.